Author(s):

Dr Bhosale PA

Abstract: Cisplatin(Cis- Diammine dichloroplatin(II), is a divalent, inorganic, water soluble, platinum containing complex drug is especially useful in the treatment of epithelial malignanciesbut excess dose dtect cytotoxicity.. In aquatic ecosystem of heavy metals are the most important pollutants in aquatic ecosystems. In this study, histopathological effects of cisplatin and their incidence time were studied. Exposure to chronic dose of cisplatin was done by the harmful action of the bivalve molluscs were during 20 days and histopathological investigations were conducted in mantle, digestive gland and foot in days 0, 10, 15, and 20. Shows changes observed the damages of epithelium cells with increasing mucous cells (in mantle), atrophy of digestive tubules and haemocyte aggregation (in digestive gland), and hyperplasia, increasing mucous cells and myocyte swelling (in foot). Moreover, granuloma and tissue rupture were found in all organs. Primary histopathological changes were observed in tenth day of examination in all of studied organs. Results showed that sensitivity of digestive gland is lesser than mantle and foot in exposure to cisplatin . Also the results indicated the histopathological alterations in the organs of Corbicula striatella can be considered as reliable biomarkers in biomonitoring of cisplatin toxicity in aquatic ecosystems.

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