Abstract:
Objective: The aim of the present work was to evaluate anticandidal activity of
Mentha piperita and
Pongamia pinnata essential oils and synergistic anticandidal activity of these essential oils with some commonly used commercial antibiotics like Amphotericine B, Nystatin, Fluconazole, Ketoconazole, Clotrimazole and Itraconazole against multidrug resistant clinical isolates of
Candida. Method: The synergistic effect of antifungal activity was evaluated against clinical isolates by disc diffusion assay.
Results: The synergistic activity of the antibiotics with
Piper mentha essential oil was better than with that of
Pongamia pinnata essential oil.
Piper mentha essential oil increased the
anti-candidal effect of azole antibiotics Fluconazole and Ketoconazole, while it had less synergistic effect on Clotrimazole and Itraconazole.
Conclusion: The essential oil of
Piper mentha essential oil in combination with antibiotics could be used as an interesting and alternative source of anticandidal agent against
Candida species.
Tejas Rathod, Hemali Padalia and Sumitra Chanda. Chemical constituents of Mentha piperita and Pongamia pinnata essential oils and their synergistic anticandidal activity with some antibiotics against multidrug resistant clinical isolates of Candida. J Pharmacogn Phytochem 2017;6(5):579-589.