Journal of Pharmacognosy and Phytochemistry
Vol. 6, Issue 5 (2017)
Ethanol-induced gastric ulceration in rats: Protective roles of methanol and water extracts of Cyathula prostrata Linn Blume
Dauda K Richard, Aliyu Jauro, John B Nvau and Luka J Dabun
The study investigated gastro protective effect of methanol and water, crude extract of Cyathula prostrata
against ethanol induced gastric ulcer in rats. Ulceration was induced by oral administration of absolute ethanol (1cm3
/kg body weight). Wistar rats were pre-treated with Omeprazole 20mg/kg body weight, 50mg/kg, 100mg/kg and 150mg/kg per body weight of methanol and water extract separately. These extracts showed a marked deduction in the mean ulcer index parameter studied on the test animals in a dose dependence manner with a significant increase in percentage preventive index. In conclusion, it was observed that the methanol and water extract of Cyathula prostrata
provides a significant anti-ulcer effect against ulcer in rats, a fact that supports the traditional use of hot water extract of the whole plants for its anti-ulcer effect.
Pages: 1515-1517 | 1573 Views 371 Downloads
Dauda K Richard, Aliyu Jauro, John B Nvau and Luka J Dabun. Ethanol-induced gastric ulceration in rats: Protective roles of methanol and water extracts of Cyathula prostrata Linn Blume. J Pharmacogn Phytochem 2017;6(5):1515-1517.