Author(s):

Lal Raisa Helen, Kuriakose Jayesh, A Vysakh and MS Latha

Abstract: Clerodendrum infortunatum is a traditional Indian medicinal plant reported to be used for the treatment of inflammation, skin diseases, tumor, bronchitis etc. The anti-inflammatory activity of various extracts of the root bark of Clerodendrum infortunatum were screened by proteinase inhibitory assay and nitric oxide scavenging assay. The total phenolic content was evaluated by Folin-Ciocalteu method. The correlation between anti-inflammatory activity and phenolic content was also carried out. The active extract was tested against carrageenan induced paw edema. Aqueous acetone extract was found to possess maximum anti-inflammatory activity in the in vitro screening study and the phenolic content correlates with the antiinflammatory activities. In the carrageenan induced acute inflammatory study, administration of the aqueous acetone extract significantly reduced the paw volume in carrageenan treated rats. The haematological, biochemical and histopathological findings also points to the antiinflammatory activity of the extract. Thus the phenolic compounds present in the root bark of the plant may be responsible for the activities exhibited by the plant and hence it can be used against inflammatory diseases.

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