Author(s):

Amrita Sutradhar, Arghya Prosun Sarkar, Md. Abu Saleh, Milon Mondal, Tania Binte Wahed, Sohel Ahmed, KM Khairul Alam and Sukalyan Kumar Kundu

Abstract: Diabetes and hyperlipidemia are two major threats to human health. Importantly, these two events coexist in most of the case studies. Our objective of the study was to investigate antidiabetic and antilipidemic effect of fruit extract of Spondias pinnata in Alloxan induced hyperglycemic rats. Thirty six Sprague Dawley rats were divided into six groups. Thirty of them were induced diabetes by IP administration of Alloxan monohydrate at a single dose of 150 mg/kg BW. Group I, II and III were given methanol extract of fruits of Spondias pinnata at a daily single dose of 250 mg/kg, 500 mg/kg and 1000 mg/kg BW, respectively for 21 days. Group IV was given Metformin HCl as standard drug at a daily single dose of 100 mg/kg BW for 21 days. Group V was kept as diabetic control group. Group VI rats were not induced hyperglycemia and served as normal control group. The fasting blood glucose levels were lower in Group I, II, III and IV compared to diabetic control group. On 21^st day, sacrificing the rat’s blood was collected and prepared for further tests. The lipid parameters such as serum Triglycerides, Total Cholesterol, Low Density Lipoprotein and Very Low Density Lipoprotein were significantly reduced, whereas High Density Lipoprotein (HDL) level was significantly increased in Group I, II, III and IV compared to the diabetic control group. Atherogenic index and Coronary risk index were also lower in Group I, II and III compared to diabetic control group. Thus it can be claimed that this fruit has a mild antidiabetic property and a good prospect for discovery of some lead compounds against hyperlipidemia. Finally, it might be concluded that this fruit can be a good choice for the control of hyperlipidemia and thereby many other relevant consequences like diabetes and hypertension.

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