Author(s):

Jajati Pramanik, Indrajit Giri, Milan Kumar Maiti, Suman Das and Pallab Dasgupta

Abstract: The study was done to evaluate the efficiency of Arthrito at different concentration for anti-inflammatory and anti-arthritic activity by HRBC membrane stabilization method and inhibition of protein denaturation method. HRBC membrane stabilization method was chosen for this experiment because of its simple, reliable, less toxic and less time consuming. HRBC membrane stabilization was similar to lysosomal membrane which influences the process of inflammation. In this experiment arthrito shows its membrane stabilizing activity over all concentration that was important for inflammation. Diclofenac sodium which was used as a standard drug in the experiment shows maximum membrane stabilization as well as protein denaturation property. To limiting the inflammatory response lysosomal membrane was important because it helps the inhibition process by inhibit the release of lysosomal constituents of activated neutrophil. The extracellular release of bactericidal enzymes and protease which are the active constituents of neutrophil can cause tissue inflammation and damage. The stabilization of erythrocyte membrane implies that that arthrito can also stabilize lysosomal membrane. Protein denaturation was the main causes of inflammation in rheumatoid arthritis condition. Production of auto antigen in certain rheumatic disease was important for inflammation as well as arthritis. Arthrito was capable to control the production of auto antigen and inhibit the denaturation of protein. Thus, Arthrito is very important for anti-inflammatory and anti-arthritic activity.

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