• Printed Journal
  • Indexed Journal
  • Refereed Journal
  • Peer Reviewed Journal
Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 8, Issue 1 (2019)

Anticoagulant activities of sulfated polysaccharides from the edible marine algae Padina tetrastromatica and Ulva fasciata: A combined in vitro and in vivo approach

Author(s):

Lekshmi VS and G Muraleedhara Kurup

Abstract:
The scientific validation of the bioactivities of sulfated polysaccharides (SPSs) from the edible marine algae glorifies the traditional aspects of their medicinal properties. The SPSs are the major structural ingredient of the algal cell wall composition. The aim of the present study is to evaluate the combined anticoagulant efficacy of SPSs purified from the edible marine algae Padina tetrastromatica and Ulva fasciata. After in vitro analysis, the results were confirmed by in vivo studies in SD rats induced with venous thrombosis. During the study, both compounds were found to have heparin-like anticoagulant properties. That is, these heparinoid-active compounds exert antithrombotic activity through the modulation of the intrinsic coagulation pathway. The overall results established that the combined effects of algal sulfated polysaccharides are more beneficial than the individual effects and they also showed excellent antiplatelet aggregation properties. In short, the study enlightened the pharmacological potential of the edible algae and their novel compounds sulfated polysaccharides.

Pages: 693-698  |  1305 Views  470 Downloads


Journal of Pharmacognosy and Phytochemistry Journal of Pharmacognosy and Phytochemistry
How to cite this article:
Lekshmi VS and G Muraleedhara Kurup. Anticoagulant activities of sulfated polysaccharides from the edible marine algae Padina tetrastromatica and Ulva fasciata: A combined in vitro and in vivo approach. J Pharmacogn Phytochem 2019;8(1):693-698.

Important Publications Links
Journal of Pharmacognosy and Phytochemistry Pharmacognosy

Journal of Pharmacognosy and Phytochemistry

Call for book chapter