Author(s):

Zekarias Gebre, Yinebeb Tariku and Venkatesan Jayakumar

Abstract: Current progress in drug discovery research and search for new novel molecules have intensified the efforts for exploring bioactive lead molecule from herbal and traditional system of medicine around all parts of world. The present resaerch highlights about bioassay guided isolation of active phytochemical from bioactive chloroform crude extract of fruits of Lantana camara (L.). Column chromatography separation of chloroform extract leads to the isolation of LC-1 to LC-3 active molecules. The structure of active lead molecules was confirmed with help of IR, 1H-NMR, 13C-NMR, DEPT-135, DEPT-95 spectral techniques. Further antimicrobial assay studies were carried out by using Pseudomonas aeruginosa, Salmonella thyphimurium, Staphylococcus aureus and Escherichia coli by disc diffusion method found that LC-2 & LC-3 is promisingly active molecule.

Pages: 1335-1342  |  1078 Views  266 Downloads

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