Author(s):

Priyanka Sharma, Rajinder Raina, Pawan Kumar Verma, Parvinder Singh, Nawab Nashiruddullah and Harpreet Kour

Abstract: The study was aimed to determine the alterations in antioxidant, biochemical and histopathological parameters in cisplatin (cDDP) induced nephrotoxicity and its protection by treatment with hydro-alcoholic extract of Cynara scolymus. Acute nephrotoxicity was induced by cDDP (12 mg/kg) in wistar rats. Nephrotoxic rats were treated with quercetin (50 mg/kg) and hydro-alcoholic floral extract (150 and 300 mg/kg body weight) by oral gavage. Cisplatin treatment elevated (P<0.05) the levels of blood urea nitrogen, creatinine, uric acid, malondialdehyde but lowered (P<0.05) total plasma proteins, total thiols, blood glutathione levels and antioxidant enzymes as compared to the control. Pre and post treatment with plant extract at 150 and 300 mg/kg attenuated the altered levels of various enzymatic and oxidative parameters in blood and renal tissue in a dose dependent manner. The extract attenuated the degenerative and necrotic changes of proximal convoluted tubules induced by cDDP which initiates the good nephroprotective potential of C. scolymus extract.

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