Author(s):

Toure Abdoulaye, Kablan Ahmont Landry Claude, Ouattara Howele and Coulibaly Adama

Abstract: Dermal and ocular irritation potentials of soap from extracts of leaves of Morinda morindoides codified "Morinda" were assessed using in vivo acute irritation tests in albino rabbits. Irritation risk of this soap Morinda was performed according conventional test for assessing skin and eye irritation potentials of chemicals with Draize rabbit test. For skin irritation test, 0.5 g dose of soap Morinda was applied to intact and abraded skin approximately 2.5×2.5 cm square of six albino New-Zealand rabbits and left in place for 24 hrs. Acute eye irritation test was carried out in nine albino rabbits. Soap Morinda at concentration of 50 mg/mL amount 0.1 mL was once placed in conjunctival sac of left eye of each animal after gently pulling the lower lid way from eye ball. Soap Morinda was non-irritating on rabbit skin test with a primary irritation index of 0.125. For eye irritancy test, this soap was weakly irritating with index of acute ocular irritation index of 2.66. Results from the present study suggest that soap Morinda made from hexane extract of M. morindoides as antimicrobial agent have promising potential medicated soap that do not induce significant levels of skin and eye irritation.j

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