Author(s):

Bibhushan Dhungyal, Chandrakala Sharma and Dilip Kumar Jha

Abstract: Leaf and inflorescence of Girardinia heterophylla is believed to be beneficial for diabetic patients by the local community of Sikkim, thus its degree of use is very high. Present study evaluated the antihyperglycemic activity of hydroethanolic extract of these two plant parts. Preliminary phytochemical analysis revealed number of phytocompounds. Streptozotocin-nicotinamide induced Type-II diabetic male albino Wistar rats were orally fed with plant extracts (200 and 400 mg/kg body weight) for 28 consecutive days. There was significant (p<0.05) dose dependent decrease in the blood glucose level in the experimental group as compared to the diabetic control group (percentage reduction of 37.29% and 45.54% by leaf extract, 65.46% and 66.67% by inflorescence extract at two different concentrations). Normalization of body weight was also observed. Results of the present study strongly indicate that leaves and inflorescences of Girardinia heterophylla have antihyperglycemic potential and can be source for the isolation of active compound(s).

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