Author(s):

Leena Raju Dhoble, Dr. Prakash R Itankar and Dr. Satyendra K Prasad

Abstract: Senna, a plant of ethnopharmacological importance has been traditionally used in the treatment of chronic constipation. Ancient texts from Ayurveda have mentioned the potency of Senna as a laxative. The traditional methods incorporated for formulation of Senna for the treatment of constipation, suffer from inherent drawbacks like compound-specific isolation and extraction, lack of standardisation, safety and efficacy standards and non availability in modern dosage forms. Therefore, it was proposed to prepare uncoated oral dosage form tablets of optimized and enriched extracts from dried Senna leaves. It was also envisaged to standardize the product making it acceptable for the modern generation of end users. Maceration process was used for extraction of dried Senna leaves. The physicochemical and preliminary phytochemical screening studies were performed. Hydroalcoholic extracts were prepared in concentrations of 50%, 70%, 80% and 100% ethanol. Enrichment of the Senna extracts was done using Borntrager’s process. It was observed that 70% ethanol enriched Senna extract resulted in higher yield value as compared to the other extracts. The presence of Sennosides was asserted using TLC coupled UV analysis. In HPLC analysis, Sennoside B was used as the marker compound, wherein 70% ethanol enriched extract showed relatively higher concentration of Sennosides. Senna enriched and optimized extract tablets were prepared by using wet granulation method. Evaluation parameters of Senna tablets were found to be within the Pharmacopoeial limits. During dissolution studies, it was found that 70% enriched ethanolic extract of Senna resulted in higher % cumulative release of tablet ingredients at 90 minute time interval. Hence, 70% enriched Senna extract can be considered as the optimum concentration in terms of extraction, analysis, concentration of total Sennosides, formulation and evaluation, so as to achieve the desired therapeutic and pharmacological benefits of the product.

Pages: 2043-2048  |  4034 Views  2844 Downloads

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