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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 8, Issue 2 (2019)

In silico molecular docking studies of isolated phytochemicals from the Ledebouria genes as COX-2 inhibitors

Author(s):

B Soni Veena and E Sujatha

Abstract:
Ledebouria is a genus of weakly evergreen bulbs in the Hyacinthaceae family. The anti-inflammatory activities of the isolated phytochemicals 1-4 from the bulbs of the Southern African Ledebouria socialis and Ledebouria ovatifolia were evaluated against cyclooxygenase-1 and cyclooxygenase-2 isoenzymes. All the compounds exhibited significant activity against cyclooxygenase-2 at <10 µM. In this report, to study the possible interactions of isolates with the crystal structure of human cyclooxygenase-2 (PDB ID: 5F1A) from the molecular docking studies. Among all compounds, compound 2 exhibited higher COX-2 inhibitory activity (IC50 = 2.87±1.2 µM) was supported by highest docking score of 139.079 in molecular docking studies.

Pages: 2231-2235  |  1222 Views  562 Downloads


Journal of Pharmacognosy and Phytochemistry Journal of Pharmacognosy and Phytochemistry
How to cite this article:
B Soni Veena and E Sujatha. In silico molecular docking studies of isolated phytochemicals from the Ledebouria genes as COX-2 inhibitors. J Pharmacogn Phytochem 2019;8(2):2231-2235.

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