• Printed Journal
  • Indexed Journal
  • Refereed Journal
  • Peer Reviewed Journal
Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 8, Issue 2 (2019)

Effect of Platycladus orientalis on the serum biochemical markers of oxidative stress in liver cirrhosis with histopathological microscopic study

Author(s):

Alok Kumar Dash and Jhansee Mishra

Abstract:
Objective: The aim of the present study evaluates the hepatoprotective effect of aqueous and petroleum ether extract of Platycladus orientalis leaf by paracetamol-induced liver damage in rats.
Materials and Methods: Hepatic damage, as reveled by histology and the increased activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) activities, and decreased levels of serum total protein (TP), albumin (Alb) were induced in rats by an administration of paracetamol (750 ± 5) mg/kg. Further, the effects of both extracts on serum thiobarbituric (TBAR), glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) were estimated to measure the degree of protection.
Results: petroleum ether extract of Platycladus orientalis at a dose level of (200 ± 5) mg/kg produce significant hepatoprotection by decreasing the activity of serum enzymes, while they significantly increased the levels of (GSH), (SOD) and (CAT) in a dose dependent manner. The effects Platycladus orientalis extract were comparable to that of standard drug, silymarin.
Conclusion: From this study, it can be concluded that the aqueous and petroleum ether extracts of Platycladus orientalis possesses both effective hepatoprotective as well as significant antioxidant activity.

Pages: 2339-2346  |  946 Views  366 Downloads


Journal of Pharmacognosy and Phytochemistry Journal of Pharmacognosy and Phytochemistry
How to cite this article:
Alok Kumar Dash and Jhansee Mishra. Effect of Platycladus orientalis on the serum biochemical markers of oxidative stress in liver cirrhosis with histopathological microscopic study. J Pharmacogn Phytochem 2019;8(2):2339-2346.

Important Publications Links
Journal of Pharmacognosy and Phytochemistry Pharmacognosy

Journal of Pharmacognosy and Phytochemistry

Call for book chapter