Journal of Pharmacognosy and Phytochemistry
Vol. 8, Issue 3 (2019)
Anti-leishmanial activities of some compounds of Tarchonanthus camphoratus leaf surface exudates
Author(s):
Okemwa Evans Kenanda and Leonidah K Omosa
Abstract:
One sesquiterpene, (-)-parthenolide (1), and four known methoxylated flavonoids; 5,7,3´,4´-tetrahydroxy-3-methoxyflavone (2), 5,7,4´-trihydroxy-6-methoxyflavone (3), 5,7,3´,4´-tetrahydroxy-6-methoxyflavone (4) and 5-hydroxy-7,8-dimethoxyflavanone (5) were characterized from leaf surface exudates of
Tarchonanthus camphoratus. The structures of the compounds were determined based on spectroscopic data analyses. Compound 2 exhibited moderate anti-leishmanial activities against
Leishmania donovani with IC
50 value of 12.84 µg/mL. (
vs 0.85 for pentamidine and 0.12 µg/mL for amphotericin B). Compound 4 and 5 also showed anti-leishmanial activities with IC
50 values of 26.24 and 23.15 µg/mL respectively. All compounds tested were not cytotoxic at 5 µg/mL.
Pages: 96-100 | 834 Views 215 Downloads
Okemwa Evans Kenanda and Leonidah K Omosa. Anti-leishmanial activities of some compounds of Tarchonanthus camphoratus leaf surface exudates. J Pharmacogn Phytochem 2019;8(3):96-100.