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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 8, Issue 3 (2019)

Rheum emodi (Rhubarb) root powder accelerates dermal wound healing by up regulating the expression of Ccr1, EGF, K6 and EGR-1

Author(s):

Sheikh Bilal Ahmad, Showkeen Muzamil, Ishraq Hussain, Showkat Ahmad Bhat, Muneeb-U-Rehman and Manzoor-Ur-Rehman Mir

Abstract:
The present study was conducted to investigate the effect of Rheum emodi (Rhubarb) root powder on the expression of wound healing genes Ccr1, EGF, Keratin 6 and EGR-1 in rabbits of different age groups. The wounds treated with Rhubarb powder showed enhanced expression of Ccr1, EGF, K6 and EGR-1 by using reverse transcription polymerase chain reaction against normal saline treated wounds in all the groups. The expression was more pronounced in group A and B treated wounds as against group C treated wounds. The Rheum emodi (Rhubarb) root powder demonstrated wound healing activity by enhancing the expression of Ccr1, EGF, K6 and EGR-1thereby confirming the therapeutic potential of Rheum emodi.

Pages: 115-121  |  1434 Views  414 Downloads


Journal of Pharmacognosy and Phytochemistry Journal of Pharmacognosy and Phytochemistry
How to cite this article:
Sheikh Bilal Ahmad, Showkeen Muzamil, Ishraq Hussain, Showkat Ahmad Bhat, Muneeb-U-Rehman and Manzoor-Ur-Rehman Mir. Rheum emodi (Rhubarb) root powder accelerates dermal wound healing by up regulating the expression of Ccr1, EGF, K6 and EGR-1. J Pharmacogn Phytochem 2019;8(3):115-121.

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