Author(s):

Shanti Vasudevan CN, Dr. Bibu John Kariyil and Dr. I’ma Neerakkal

Abstract: Pterocarpus santalinus have been traditionally used in the treatment of headache, skin diseases, fever, boils, scorpion-sting and to improve sight. However, anti-pyretic efficacy has not been scientifically validated. Therefore the study aims to investigate the antipyretic activity of its heart wood aqueous extract using brewer’s yeast induced pyrexia method. A total of thirty Wister Albino male rats weighing between 100-200g were used for this study. The method was standardized by subcutaneous injection of yeast suspension (10m/kg body weight) which increased the rectal temperature after 20 hours. Rectal temperatures were recorded at regular intervals using a digital thermometer. The aqueous extract 400mg/kg & 800mg/kg) of heart wood of P. santalinus possessed significant antipyretic activity but the effect was slow when compared to the standard antipyretic drug paracetamol (150 mg/kg body weight).

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