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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 8, Issue 3 (2019)

In vivo anti-inflammatory activity and GC-MS analysis of hydroethanolic extract of Caesalpinia bonducella seeds

Author(s):

Jagdale RA, AP Somkuwar, SK Bhoye, KG Sarode and RP Limsay

Abstract:
Objective: To investigate the GC-MS analysis and anti-inflammatory activity of hydroethanolic extract of C. bonducella seeds in wistar rats.
Methods: The acute anti-inflammatory activity was studied by Carrageenan induced rat paw edema while chronic anti-inflammatory activity by cotton pellet induced granuloma model.
Results: The GC-MS analysis showed presence of 32 phytoconstituents. Among these 16 compounds which were previously reported for the presence of various biological activities. From the study, it was shown that the extract significantly inhibited paw volume in acute inflammation and weight of granuloma formation in chronic inflammation at both the doses in dose dependent manner.
Conclusion: From the results obtained, it was concluded that the C. bonducella extract possesses significant anti-inflammatory activity which validated its ethnopharmacological use in treatment of inflammation.

Pages: 929-934  |  1231 Views  504 Downloads


Journal of Pharmacognosy and Phytochemistry Journal of Pharmacognosy and Phytochemistry
How to cite this article:
Jagdale RA, AP Somkuwar, SK Bhoye, KG Sarode and RP Limsay. In vivo anti-inflammatory activity and GC-MS analysis of hydroethanolic extract of Caesalpinia bonducella seeds. J Pharmacogn Phytochem 2019;8(3):929-934.

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