Author(s):

Kamalarajan P and Valan MF

Abstract: Inflammation induced by carrageenan is acute, non-immune, well-researched, and highly reproducible. The anti-inflammatory activity of test compounds by examining their ability to reduce or prevent the development of carrageenan-induced paw swelling is one of the important studies. In the present study attempts are made to validate the anti-inflammatory activity of Methanolic extract of Mollugo cerviana. The anti-inflammatory activity of the Methanolic extract of Mollugo cerviana was evaluated by carrageenan-induced rat paw oedema method. The number of migrating leukocytes in the exudates was determined. The Methanolic extract of Mollugo cerviana reduced the edema induced by carrageenan by 55.48% and 57.62% on oral administration of 100 and 200 mg/kg, as compared to the untreated control group. Animals treated with the Methanolic extract of Mollugo cerviana and standard produced a leukocyte migration of 0.55±0.06×10³, 0.51±0.05x10³ and 0.47±0.04×10³ cells/ml, respectively. The pleurisy model showed that the Methanolic extract of Mollugo cerviana behaves as an inhibitor of leukocyte migration and the formation of pleural exudates.

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