Journal of Pharmacognosy and Phytochemistry
Vol. 8, Issue 3 (2019)
Assessment of anti-arthritic, antiâ€inflammatory and antioxidant activity of Melia dubia
HN Krishna Kumar and Jyoti Bala Chauha
The present investigation deals with the phytochemical screening, anti-arthritic, antiâ€inflammatory
and antioxidant potentials of ethanolic fruit extract of Melia dubia
. Phytochemical screening studies of the extract showed the presence of flavonoids, steroids, saponins, alkaloids, glycosides and tannins. Evaluation of total phenolic contents revealed that the extract contains 142.8 mg/g of phenolic compounds. The antioxidant activity of the extract was evaluated through DPPH assay and reducing power assay. The free radical scavenging activity of the extract was confirmed in a DPPH assay. The extract showed the stronger radical scavenging effect with IC50
value of 55.4μg /ml. The reducing power of the extract observed was concentration dependent which is comparable with the standard antioxidant butylated hydroxyanisole (BHA). The plant exhibited good anti-arthritic activity in a dose dependent manner. The extract showed highest inhibitory activity of 81.2% with an IC50
value of 58.2 μg/ml. Likewise, the fruit extract of Melia dubia
showed strong antiâ€inflammatory activity in a concentration dependent manner with an IC50
value of 52.6 μg/ml.
Pages: 2579-2582 | 1053 Views 426 Downloads
HN Krishna Kumar and Jyoti Bala Chauha. Assessment of anti-arthritic, antiâ€inflammatory and antioxidant activity of Melia dubia. J Pharmacogn Phytochem 2019;8(3):2579-2582.