Author(s):

Saranya Nallusamy, Kandavelmani Angamuthu and Sathyaseelan Chakkarai

Abstract: Cyclin-dependent kinases (CDK) are one of the important drug targets for the inhibition of the cancer cell growth. Numbers of natural compounds from plants possessing CDK inhibitory activity have been reported in NPACT (Naturally Occurring Plant-based Anti-cancer Compound-Activity-Target) database. Compounds derived from plants have higher potency to act as effective drugs due to its reduced nature of toxicity. To understand the molecular interaction of plant derived compounds and clinical drugs reported for target CDK, a comparative analysis have been performed based on the docking and similarity analysis using various bioinformatics software and tools. In similarity analysis, all against all comparison of all the CDK inhibitors was performed based on the tanimoto similarity values. Outcome of the present study would provide a thorough knowledge on the available drugs and plant derived compounds. In addition it would also enhance the vision towards novel CDK drug design strategy.

Pages: 2050-2062  |  779 Views  260 Downloads

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