Author(s):

Dr. S Alagendran, Dr. N Pushpa, Dr. Gaby Fernandez, A Senthil Kumar and Dr. D Jayakumar

Abstract: The aim of the study is to find out the whether an extract of brahmi leaves might be highly putative in dementia type Alzheimer's disease. Bacopa monnierri. L is used traditionally as alternative and complementary medicine for memory deficits/enhancer. Different solvent extraction is used for protein quantitation and assessing total phenolic content in brahmi leaves. The two different ways of extraction using phenol-chloroform and TCA which also predicts to find out the protein n correlation with total phenolic content in brahmi leaves shows exceedingly raise as 86.7±5.3 mgGAE/g, this is due to the effects of polyphenolic and flavoanoid contents present in leaves of brahmi has natural antioxidants role to treat memory deficits in aging falls. Further, to characterize low molecular weight protein present in brahmi leaves isolated gel was quantified by mass spectrophotometry represent β-amyloid precursor protein, tau and GABA predominantly present in Bacopa Monnierri L. as a putative biomarker for dementia type Alzheimer's disease.

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