Development of a modified hypercholesterolaemic rat model to study the efficacy of hypocholesterolaemic therapeutic agents

KAV Sumudunie; DI Uluwaduge

Development of a modified hypercholesterolaemic rat model to study the efficacy of hypocholesterolaemic therapeutic agents

Author(s):

KAV Sumudunie and DI Uluwaduge

Abstract:

Raised cholesterol increases the risk of heart disease and stroke. The management of hypercholesterolaemia by administration of hypocholesterolaemic agents, either in the form of novel pharmaceuticals or herbs, is a major research area at present. A hypercholesterolaemic animal model is a prime requirement to test the efficacy of the testing agent. According to the literature the cost is very high for the establishment of hypercholesterolaemic rat model using commercial cholesterol. The present work aimed at establishing a dietetic rat model capable of promoting a moderate level hypercholesterolaemia to be used in the area of lipid research.

Hypercholesterolemia was induced by feeding a diet containing 10% butter incorporated into standard rat and mice feed formula for a period of twelve weeks. Fasting serum cholesterol levels were measured at four, eight and twelve week intervals.

The fasting serum cholesterol concentration of rats fed on hypercholesterolaemic diet was found to be significantly higher (p<0.05) compared with the control group.

Present study confirms the development of a diet based, cost-effective and time efficient experimental rat model, to explore the efficacy of novel therapeutics in the area of lipid research.

Pages: 2393-2395 | 775 Views 247 Downloads

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Journal of Pharmacognosy and Phytochemistry

How to cite this article:

KAV Sumudunie and DI Uluwaduge. Development of a modified hypercholesterolaemic rat model to study the efficacy of hypocholesterolaemic therapeutic agents. J Pharmacogn Phytochem 2019;8(5):2393-2395.

Pharmacognosy

Journal of Pharmacognosy and Phytochemistry

Vol. 8, Issue 5 (2019)

Development of a modified hypercholesterolaemic rat model to study the efficacy of hypocholesterolaemic therapeutic agents

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