Author(s):

AA Bhingare, Rd Bhalke, K Vanitha Prakash, Sanjay B Kasture And MA Giri

Abstract: Depression is major serious CNS disorder occurring in world which recorded about 450 million people suffer from mental or behavioural disorder according to world health report (Murugan, 2011). In the traditional systems of medicine, many plants have been used to treat depression for thousands of years. For screening of antidepressant activity tail suspension test, forced swim test and splash test have been used. During the study of Ascorbic acid (AA) (5 /10 mg/kg i. p.), Caffeine (5 mg/kg i.p.) sertraline (5 mg/kg i.p.) and fluoxetine (10 mg/kg p.o.) were administered individually and in combination. Ascorbic acid and caffeine combination at (5+5 mg/kg) has shown significant (P<0.01) increased in latency to immobility. A significant (P<0.01) decrease in the duration of immobility was seen in all treatment but marked result is shown in C + S (5+5 mg/kg) treated group. A significant (P<0.01) increase in time spent in climbing in Caffeine (5 mg/kg) treated group is observed. Sertraline and caffeine combination at (5+5 mg/kg) showed significant increase in time spent in swimming. Caffeine at 5 mg/kg has shown significant (P<0.01) increased in latency to immobility in acute tail suspension test as compare to sertraline whereas significant (P<0.01) decrease in the duration of immobility was seen in all treatment but marked result is shown in C + S (5+5 mg/kg) treated group. AA + C (10+5 mg/kg) has shown significant (P<0.01) decreased in latency to grooming whereas significant (P<0.01) increase in the duration of grooming was seen in AA (10mg/kg) and AA + C (10+5 mg/kg) treated groups. Present study was undertaken to evaluate the antidepressant potential ascorbic acid, caffeine, sertraline and their combinations.

Pages: 474-480  |  908 Views  325 Downloads

Download (839KB)