Author(s):

S Kannadas, RN Pathirana and WD Ratnasooriya

Abstract: The study determined the in-vitro anti-inflammatory activity and the phytochemical profile of aqueous seed extract of Eclipta prostrata (L.). The egg albumin denaturation assay was done using aqueous seed extract of Eclipta prostrata (L.). The diclofenac sodium drug was used as the reference. The aqueous seeds extract of Eclipta prostrata (L.) showed a moderate dose dependent inhibition of egg albumin denaturation with an IC₅₀ value of 1.710 ×10³ μg/mL (r²=0.9598, p<0.05) and diclofenac sodium showed a dose dependent inhibition of protein denaturation with an IC₅₀ value of 794 μg/mL (r²=0.984, p<0.05). The anti-inflammatory activity of the seed extract was less potent when compared with the reference drug. However, the extract showed a significant anti-inflammatory activity. The phytochemical profile of Eclipta prostrata (L.) aqueous seed extract revealed the presence of phenols, alkaloids, carbohydrates, steroid, terpenoids and tannins. The extract is likely to mediate its anti-inflammatory activity due to the presence of these phytochemicals. This novel findings scientifically justified the claim made by Sri Lankan traditional medicine in the use of seed extracts of Eclipta prostrata (L.) as a treatment for inflammation.

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