Author(s):

Folawiyo Moshood Abiola, Ajibare Ayodeji Johnson, Adefisayo Modinat Adebukola, Adeleye Gbenga Sunday and Ajike Adedamola Richard

Abstract: Cognitive effect of hydromethanolic leaf extract of O. gratissimum (HMOG) was evaluated in mice. Twenty four male mice weighing between 25-30 g were randomly assigned into four groups of 6 mice each. Group 1 received distilled water and served as control, group 2, 3 and 4 received 10 mg/kg body weight (b.wt.) of Ginkgo biloba (standard drug), 200 and 400 mg/kg b.wt. of HMOG respectively for 21 consecutive days. Data were analyzed using one-way and student`s t-test, where p< 0.05 was considered significant. Qualitative phytochemical screening of HMOG done indicated the presence of flavonoids, alkaloids, glycosides and tannins. The cognitive indices: latency to alternate and percentage spontaneous alternation (% SA) showed a significant decrease (p< 0.001) respectively when compared with the control and the standard drug group. This study concluded that HMOG improved cognition in mice which may be attributed to the phytochemicals in the extract.

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