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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 9, Issue 3 (2020)

Evaluation of neuropharmacological and analgesic activities of methanolic extract of Diospyros blancoi A. DC leaves in Swiss albino mice

Author(s):

Md. Rashidur Rahman, Trina Mony, Sonia Akter, Koushik Ahamed and Afrina Afrose

Abstract:
This research work was carried out to evaluate the neuropharmacological and analgesic activities of methanolic extract of Diospyros blancoi leaves by experimenting Swiss albino mice. The neuropharmacological activities of methanol extract were conducted using hole cross, force swimming and tail suspension tests. On the other hand, analgesic activities of the extract were performed using acetic acid induced writhing and hot plate tests. The mice were treated orally at dose of 200 mg/kg and 400 mg/kg of leaves extract for neuropharmacological and analgesic tests. The methanolic leaves extract of Diospyros blancoi significantly (p<0.05) showed neuropharmacological and analgesic activity. This confirms the traditional uses and indicates further investigation to isolate the active phytochemical constituents and to understand the pharmacological mechanism of the chemical compounds present in the leave parts of this plant.

Pages: 2121-2126  |  1303 Views  660 Downloads


Journal of Pharmacognosy and Phytochemistry Journal of Pharmacognosy and Phytochemistry
How to cite this article:
Md. Rashidur Rahman, Trina Mony, Sonia Akter, Koushik Ahamed and Afrina Afrose. Evaluation of neuropharmacological and analgesic activities of methanolic extract of Diospyros blancoi A. DC leaves in Swiss albino mice. J Pharmacogn Phytochem 2020;9(3):2121-2126.

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