Author(s):

Fatma Elshibani, Abdullah Alamami, Salmin Alshalmani, Esra A El Naili, Hala A Gehawe, Mohamed Ali Sharkasi and Naema Elremali

Abstract: The methanolic extract of Capparis spinosa was studied to evaluate the phenolic content, and flavonoid content, α-amylase inhibition and antioxidant activities using in-vitro methods. The extraction of the medicinal plant was carried out by maceration in methanol. The findings revealed the presence of elevated amounts of phenols and flavonoids in C. spinosa. The phenolic content was 555±0.5mg gallic acid equivalent per gram, while the flavonoid content was 102.59±0.6mg rutin equivalent per gram. The plant displayed a considerable free radical scavenging activity on DPPH with IC₅₀ of 0.07±0.02mg/ml in comparison to the standard antioxidant gallic acid (IC₅₀ 0.03±0.002mg/ml). The α-amylase inhibitory activity of the extract exhibited an IC₅₀ value of 0.34±0.003mg/ml compared to the reference drug acarbose (0.064±0.001mg/ml). The methanolic extracts of the aerial parts of C. spinosa have significant antioxidant and α-amylase inhibitory activities. This outcome indicates that caper can be employed in the development of plant-based foods for the treatment of diabetes mellitus.

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