Author(s):

C Pramod, Ratheesh M, Svenia P Jose and Stephy Jose

Abstract: It is traditionally used for its various properties, and hence in the present study, alcoholic extract of Trema orientalis L. Blume (EETO) leaves has been screened for its hypolipidemic activity. Hypolipidemic activity is screened by inducing hyperlipidemia with the help of Fructose induced rat model, Triton x 100 induced model and serum levels of various biochemical parameters such as total cholesterol, triglycerides, LDL, VLDL and HDL cholesterol were determined. The atherogenic index shows the measure of the athero-genic potential of the drugs. The alcoholic extract showed significant (p < 0.05) hypolipidemic effect by lowering the serum levels of biochemical parameters such as a significant reduction in the level of serum cholesterol, triglyceride, LDL, VLDL and increase in HDL level which was similar to the standard drug Simvastatin. The alcoholic extract exhibited significant atherogenic index and percentage protection against hyperlipidemia. The EETO possesses significant antioxidant activity evidenced by elevated levels of glutathione reductase and Glutathione peroxidase compared to the hyperlipidemic group. The ratio of HMG-CoA to mevalonate is an index of enzyme activity which catalyses the conversion of HMG to mevalonate. These biochemical observations were, in turn, confirmed by histopathological examinations of liver sections and are comparable with the standard hypolipidemic drug Simvastatin. The overall experimental results suggest that the biologically active phytoconstituents such as flavonoids, glycosides alkaloids present in the alcoholic extract of Trema orientalis L. Blume (EETO). The leaves may be responsible for the significant hypolipidemic activity, and the results justify the use of Trema orientalis L. Blume as a significant hypolipidemic agent.

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