• Printed Journal
  • Indexed Journal
  • Refereed Journal
  • Peer Reviewed Journal
Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 10, Issue 1 (2021)

Assessment of the acute, subacute and Subchronic toxicity of a total aqueous extract of leaves of Alchornea cordifolia (Schumach and Thonn) Müll Arg (Euphorbiaceae) on rats Wistar

Author(s):

Gnahoué Goueh, Koné Allassane, Kouadio Koffi John and Kouakou Koffi

Abstract:
The leaves of Alchornea cordifolia are traditionally used by African populations for the treatment of several diseases. The acute toxicity study concluded that the total aqueous extract of Alchornea cordifolia (ETAAC) is not toxic by single administration and that its LD50 is greater than 5000 mg/kg of body weight (bw). Tests carried out by daily administration of ETAAC did not result in any significant change in the body weight of the animals and the weight of vital organs. After 28 days of treatment, no significant difference was observed in the figurative elements of the blood and in the biochemical parameters. Significant decreases were observed in urea and alanine-amino transferase after 60 days of treatment. Alchornea cordifolia does not affect the functioning of the kidneys, liver and heart. It is therefore not toxic at doses of 100 mg/kg of bw, 200 mg/kg of bw and 400 mg/kg of bw in rats.

Pages: 1609-1614  |  943 Views  346 Downloads


Journal of Pharmacognosy and Phytochemistry Journal of Pharmacognosy and Phytochemistry
How to cite this article:
Gnahoué Goueh, Koné Allassane, Kouadio Koffi John and Kouakou Koffi. Assessment of the acute, subacute and Subchronic toxicity of a total aqueous extract of leaves of Alchornea cordifolia (Schumach and Thonn) Müll Arg (Euphorbiaceae) on rats Wistar. J Pharmacogn Phytochem 2021;10(1):1609-1614. DOI: 10.22271/phyto.2021.v10.i1w.13576

Important Publications Links
Journal of Pharmacognosy and Phytochemistry Pharmacognosy

Journal of Pharmacognosy and Phytochemistry

Call for book chapter