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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 10, Issue 2 (2021)

Chemical constituents and antifungal effects of Hyptis lanceolata Poir.

Author(s):

Antoine Salvial Tcheuko, Judith Liliane Djouaka Bavoua, Alain Tadjong Tcho, Willifred Dongmo Tékapi Tsopgni, Alain Francois Kamdem Waffo, and Jean Duplex Wansi

Abstract:
This work focuses on the chemistry and antifungal effects of Hyptis lanceolata Poir. (Lamiaceae) a Cameroonian species. The phytochemical study led to the isolation and characterization of twelve known compounds. Seven triterpenes, namely betulin (1), betulinic acid (2), lupeol (3), α-amyrin (4), ursolic acid (5), oleanolic acid (6), and taraxerol (7), three phytosterols, stigmasterol (8), β-sitostrol (9) and β-sitosterol-3-O-β-D-glucopyranoside (10), two fatty acid namely hexadecanoid acid (11) and hexacosanol (12). The structures of these compounds were elucidated on the basis of their NMR and ESIMS experiments, in comparison with those reported in the literature. The crude extract and isolated compounds were evaluated for their antifungal activities on three fungal strains Candida albicans, Candida krusei and Candida parasilosis. Compound 5 and 6 showed significant antifungal activity on the strain Candida krusei with the same MIC value of 62.5 µg/mL while compounds 1, 2, 11 and 12 showed weakly activity with the same MIC value of 125 µg/mL. The crude extract, compounds 11, 1 and 2 exhibited weakly activity on the strain Candida albicans with the same MIC value of 125 µg/mL while compounds 6 and 11 showed weakly activity on Candida parasilosis with the same MIC value of 125 µg/mL.

Pages: 831-834  |  819 Views  319 Downloads


Journal of Pharmacognosy and Phytochemistry Journal of Pharmacognosy and Phytochemistry
How to cite this article:
Antoine Salvial Tcheuko, Judith Liliane Djouaka Bavoua, Alain Tadjong Tcho, Willifred Dongmo Tékapi Tsopgni, Alain Francois Kamdem Waffo, and Jean Duplex Wansi. Chemical constituents and antifungal effects of Hyptis lanceolata Poir.. J Pharmacogn Phytochem 2021;10(2):831-834.

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