Introduction: The bioavailability of some drugs may increase due to the absorption of the drug in the oral cavity. The objective of the study is used to formulate mouth dissolving tablets of levocetirizine dihydrochloride using super disintegrants like sodium starch glycollate and croscarmellose sodium which provide immediate disintegration of tablet after putting on the tongue, thereby releasing the drug in saliva.

Methods: Mouth dissolving tablets of levocetirizine dihydrochloride 5mg was formulated using croscarmellose sodium, starch glycollate, and crospovidone in different concentrations by direct compression method. Out of twenty-eight formulations designed, fifteen formulations were made by using different concentrations of super disintegration, and the remaining formulated by formulation optimization of the best batch using central composite design. Different types of evaluation parameters were determined.

Results: The formulation containing the combination of croscarmellose sodium, and sodium starch glycollate at the highest ratio showed the least disintegration time.

Conclusions: Croscarmellose sodium proves to be the most efficient disintegrants followed by sodium starch glycollate and crospovidone.