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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 10, Issue 2 (2021)

Formulation and evaluation of levocetirizine dihydrochloride mouth dissolving tablets

Author(s):

Anil Prasad Shah, Panna Thapa, Jit Narayan Sah and Rajan Kumar Sah

Abstract:
Introduction: The bioavailability of some drugs may increase due to the absorption of the drug in the oral cavity. The objective of the study is used to formulate mouth dissolving tablets of levocetirizine dihydrochloride using super disintegrants like sodium starch glycollate and croscarmellose sodium which provide immediate disintegration of tablet after putting on the tongue, thereby releasing the drug in saliva.
Methods: Mouth dissolving tablets of levocetirizine dihydrochloride 5mg was formulated using croscarmellose sodium, starch glycollate, and crospovidone in different concentrations by direct compression method. Out of twenty-eight formulations designed, fifteen formulations were made by using different concentrations of super disintegration, and the remaining formulated by formulation optimization of the best batch using central composite design. Different types of evaluation parameters were determined.
Results: The formulation containing the combination of croscarmellose sodium, and sodium starch glycollate at the highest ratio showed the least disintegration time.
Conclusions: Croscarmellose sodium proves to be the most efficient disintegrants followed by sodium starch glycollate and crospovidone.

Pages: 125-128  |  2627 Views  788 Downloads


Journal of Pharmacognosy and Phytochemistry Journal of Pharmacognosy and Phytochemistry
How to cite this article:
Anil Prasad Shah, Panna Thapa, Jit Narayan Sah and Rajan Kumar Sah. Formulation and evaluation of levocetirizine dihydrochloride mouth dissolving tablets. J Pharmacogn Phytochem 2021;10(2):125-128.

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