Journal of Pharmacognosy and Phytochemistry
Vol. 10, Issue 2 (2021)
Evaluation of purity, acute, cyto and subchronic – toxicities of a polyherbal Foraiammulation “FEM-Q®” used in Nigeria in the treatment of female infertility
Ogbonnia Steve, Okoh Ginika, Okeke Anthony, Ezemenahi SF and Ota Duncan
Plants have served as potential therapeutic weapons making them a sine qua non to lives.
Objective: This study evaluated the microbial purity, and toxicities of FEM Q ELIXIR®, used in treatment of female infertility.
Materials and Methods: Microbial purity was evaluated on some bacterial and fungal organisms. Acute toxicity of the extract was evaluated in Swiss albino mice orally in graded doses, and observed for 72hr while cytotoxicity was evaluated using brine shrimps and potassium dichromate in different concentrations as standard over 24 hr. Wistar rats were fed with the extract doses for 30 days and the effects on biochemical, histological and haematological parameters observed (Subchronic study).
Result: Micro-organisms were absent or within official limits. The LD50 was found to be over 20.0g/kg bwt. There is a significant difference (p≤0.05) between the LC50 of the formulation compared to LC50 of the reference standard (rf). There was no significant increase (p≥0.05) observed in body weight of the treated animals compared to control group. Also no significant (p≥0.05) difference in the organs weight variation while a significant decrease (p≤0.005) in AST and ALT levels of the animals that received the highest dose compared to the control. The histological examination revealed that the extract exerted no deleterious effects on the evaluated organs.
Conclusion: LD50 and LC50 values were above WHO toxicity index and no deleterious effects. Observed also were decreases in ALT and AST levels and no toxic effects to the hearts and other tissues.
Pages: 129-137 | 658 Views 202 Downloads
Ogbonnia Steve, Okoh Ginika, Okeke Anthony, Ezemenahi SF and Ota Duncan. Evaluation of purity, acute, cyto and subchronic – toxicities of a polyherbal Foraiammulation “FEM-Q®” used in Nigeria in the treatment of female infertility. J Pharmacogn Phytochem 2021;10(2):129-137.