Author(s):

Kirde Pranjali Prakash, Suja Rani S, Bibu John Kariyil, Nisha AR and Raji K

Abstract: The present study was aimed at toxicological evaluation of aqueous soluble fraction of methanolic extract of Tamarindus indica seed coat (AMTS) on acute oral exposure in rats and to detect photoactive constituents present in AMTS. The toxicity study was done as per Organisation for Economic Co-operation Development test guidelines No. 420, Acute Oral Toxicity-Fixed Dose Procedure, while phytochemical screening of AMTS was done by various qualitative tests. The AMTS treated rats survived throughout the study period and did not exhibit any adverse clinical signs at the limit dose level. Besides, necropsy revealed no pathological lesions in AMTS-treated rats. Furthermore, phytochemical screening revealed the presence of alkaloids, phenolic compounds, tannins, flavonoids, saponins and steroids. In summary, acute oral toxicity testing of AMTS revealed no treatment-related detrimental effects up to a dose level of 2000 mg/kg body weight, enabling it to be listed as hazard category 5/unclassified under the Globally Harmonized System.

Pages: 94-99  |  1076 Views  521 Downloads

Download (712KB)