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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 10, Issue 3 (2021)

In vitro anticancer activity of ethanolic extract of pericarp and seed parts of Momordica charantia on colon cancer cell lines

Author(s):

Dr. Purushoth Prabhu T, Deepak Venkatraman, Dr. Ravichandran S, Dr. Kabilan N and Deepak Dev

Abstract:
Objective: To investigate In vitro anticancer activity of ethanolic extract of pericarp and seed parts of Momordica charantia on colon cancer cell line.
Materials and Methods: In vitro anticancer activity was carried out by 3 (4,5 dimethylthiazol 2 yl) 2,5 diphenyltetrazolium bromide assay. Different concentrations of the ethanolic extracts were tested on cell lines HT29.
Results and Discussion: IC 50 value were determined by measuring absorbance at 570nm. The IC50 value of seed and Pericarp was found to be 62.84 µg/ml and 143.75µg/ml respectively. The Momardica charantia showed moderate to potent anticancer activity. The above results showed Momardica charantia seed was better therapeutic activity than pericarp in the treatment of colon cancer. The Therapeutic activity may be due to the phytoconstituents present in the seed extract and further the seed have to be evaluated for GCMS studies.

Pages: 224-229  |  1153 Views  456 Downloads


Journal of Pharmacognosy and Phytochemistry Journal of Pharmacognosy and Phytochemistry
How to cite this article:
Dr. Purushoth Prabhu T, Deepak Venkatraman, Dr. Ravichandran S, Dr. Kabilan N and Deepak Dev. In vitro anticancer activity of ethanolic extract of pericarp and seed parts of Momordica charantia on colon cancer cell lines. J Pharmacogn Phytochem 2021;10(3):224-229. DOI: 10.22271/phyto.2021.v10.i3c.14078

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