M Vedant Kamal, G Aadarsh Anand and Badal Parekh
Resistance to antimicrobial agents has become an increasingly important and pressing global problem. Hence, new classes of antimicrobial drugs are urgently required and, in this regard, flavonoids represent a novel set of leads.
This study was done to evaluate antimicrobial activity of synthetic quercetin analogue alone and in combination with standard drug gentamicin on gram positive and gram-negative bacteria.
Quercetin analogue was synthesized fresh in the laboratory and was used to check antimicrobial activity by agar well diffusion method in gram negative and gram-positive bacteria.
The mean of zone of inhibition given by Quercetin analogue was 3.5cm against E. coli and 3.2cm against S. aureus. The mean of zone of inhibition shown by gentamicin is 2.5cm and 2.6cm for E. coli and S. aureus respectively. Gentamicin and quercetin analogue together showed more zone of inhibition (2.9 in both bacterial strain) as compared to the control gentamicin.
As per the statistical analysis, quercetin showed significant inhibition in gram negative (E. coli) bacterial growth (p<0.001). Gentamicin showed significant inhibition in gram positive bacterial growth (p<0.035). The combination of the two showed significant bacterial growth inhibition in both bacterial strains (p<0.608).
Synthetic flavonoid (quercetin) has a potent antimicrobial activity.
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