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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 10, Issue 5 (2021)

Anthelmintic activity of leaf extract Calotropis procera

Author(s):

K Tejaswini, R Nandini, P Shireesha, Y Hemanth Kumar Reddy and K Revathi

Abstract:

Calotropis procera (Asclepiadaceae), giant milkweed, known for its various pharmacological importance for centuries to cure various diseases. It exerts many pharmacological effects such as anti-microbial, anti-pyretic, anti-cancer. Calotropis procera leaves extract was found to possess anthelmintic activity against Posthuma using mebendazole as the reference standard. The dose-dependent activity was observed in different concentrations of benzene extract of leaves. The benzene extracts of leaves at concentration 10,20,50mg/ml showed paralysis time as 4.52,3.24,1.15 min and death time as 8.27,5.26,2.66min respectively. At highest concentration produces paralysis and death in a short time which is comparable with mebendazole. Normally saline solution-treated earthworms have not shown any change in physical activity. All the data were expressed as mean ISEM. Data were subjected to one-way ANOVA. The statistical analysis was conducted with graph pad instant software (version 3, USA). The values of p<0.05 were considered statistically significant.

Pages: 303-308  |  388 Views  218 Downloads


Journal of Pharmacognosy and Phytochemistry Journal of Pharmacognosy and Phytochemistry
How to cite this article:
K Tejaswini, R Nandini, P Shireesha, Y Hemanth Kumar Reddy and K Revathi. Anthelmintic activity of leaf extract Calotropis procera. J Pharmacogn Phytochem 2021;10(5):303-308. DOI: 10.22271/phyto.2021.v10.i5d.14239

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