K Tejaswini, R Nandini, P Shireesha, Y Hemanth Kumar Reddy and K Revathi

Calotropis procera (Asclepiadaceae), giant milkweed, known for its various pharmacological importance for centuries to cure various diseases. It exerts many pharmacological effects such as anti-microbial, anti-pyretic, anti-cancer. Calotropis procera leaves extract was found to possess anthelmintic activity against Posthuma using mebendazole as the reference standard. The dose-dependent activity was observed in different concentrations of benzene extract of leaves. The benzene extracts of leaves at concentration 10,20,50mg/ml showed paralysis time as 4.52,3.24,1.15 min and death time as 8.27,5.26,2.66min respectively. At highest concentration produces paralysis and death in a short time which is comparable with mebendazole. Normally saline solution-treated earthworms have not shown any change in physical activity. All the data were expressed as mean ISEM. Data were subjected to one-way ANOVA. The statistical analysis was conducted with graph pad instant software (version 3, USA). The values of p<0.05 were considered statistically significant.

DOI: 10.22271/phyto.2021.v10.i5d.14239

Pages: 303-308  |  485 Views  266 Downloads