• Printed Journal
  • Indexed Journal
  • Refereed Journal
  • Peer Reviewed Journal
Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 11, Issue 2 (2022)

Potential inhibitory properties of selected plant secondary metabolites from local plant families in the Philippines against AcrAB-TolC drug efflux pump system of E. coli: An In silico analysis

Author(s):

Dana Isabelle A Segui, Ryne James P Gandia, Ramil Joseph P Pizarro, Julian P Soriano, Clemonne John S Madarang and Andrea G Vargas

Abstract:

Antibiotics heralded an approach to controlling and ending infectious diseases caused by bacteria. However, these life-saving drugs have begun to lose their efficacy as various bacteria have gained a significant level of antibiotic resistance over the years. Amidst these bacterial survival mechanisms, plant secondary metabolites provide a possible countermeasure against this phenomenon because of their defense mechanisms. Through in silico analytic procedures, nine selected plant secondary metabolites from Ixora coccinea, Mimosa pudica, and Origanum vulgare, in the Philippines were molecularly docked using AutoDock simulation software and Biovia Discovery Studio against the RND efflux pump system, AcrAB-TolC of E. coli. All of the selected metabolites showed negative binding energies implying high ligand-receptor affinity and good stability, especially the secondary metabolites of I. coccinea. Metabolites that have remarkable properties similar to the existing efflux pump inhibitors include lupeol, quercetin, galangin, kaempferol, and ursolic acid.

Pages: 24-32  |  861 Views  273 Downloads


Journal of Pharmacognosy and Phytochemistry Journal of Pharmacognosy and Phytochemistry
How to cite this article:
Dana Isabelle A Segui, Ryne James P Gandia, Ramil Joseph P Pizarro, Julian P Soriano, Clemonne John S Madarang and Andrea G Vargas. Potential inhibitory properties of selected plant secondary metabolites from local plant families in the Philippines against AcrAB-TolC drug efflux pump system of E. coli: An In silico analysis. J Pharmacogn Phytochem 2022;11(2):24-32. DOI: 10.22271/phyto.2022.v11.i2a.14372

Important Publications Links
Journal of Pharmacognosy and Phytochemistry Pharmacognosy

Journal of Pharmacognosy and Phytochemistry

Call for book chapter