Shahinur Akter, Roni Roy and Dr. Mohammad Anwarul Basher
Pycreus polystachyos is a well-known weed grown typically in ditches, grasslands, rice fields, etc. The whole plant is traditionally used against diarrhea. The present study was aimed to examine antidiarrheal of whole plant of Pycreus polystachyos in male and female mice model. Antidiarrheal activity was evaluated using two tests such as castor oil induced diarrhea and castor oil induced enteropooling at three extract concentrations- 100, 200 and 400 mg/kg.bw. Total flavonoids and tannins contents were also measured. The plant extract showed potent effect in prevention of castor oil induced diarrhea. Mice of both sexes showed greater effect than standard drug loperamide at 400 mg/kg.bw; the effect was substantially higher in male mice than female producing 64.77% and 38.04% in male and female respectively. Loperamide produced 35.28% and 33.70% inhibition in male and female mice respectively. In enteropooling test, both percent reduction in weight and volume of intestinal content were increased as doses of extract increased. Potent inhibition in intestinal fluid accumulation was evident from percent reduction in mean fluid volume. Male and female mice showed fluid reductions by 45.87% and 33.29% respectively while loperamide reduced it by 44.73% and 25.32%. Total flavonoids and tannins contents were found 13.44 mg Quercetin equivalent/g and 118.5 mg Gallic Acid equivalent/g respectively. The experiment endorses the folkloric use of P. polystachyos in diarrhea.
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