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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 11, Issue 2 (2022)

In vitro release and stability assessment of Origanum compactum liposomal dispersion with antifungal activity

Author(s):

Merima Ibišević, Ivana Nešić, Saša Pilipović, Aida Smajlović, Nahida Srabović, Vesna Nikolić, Dragan Cvetković, Ermina Cilović Kozarević, Emir Horozić, Enida Karić and Goran Nikolić

Abstract:

Origanum compactum, an endemic Moroccan medicinal herb, possesses many different activities such as antibacterial, antifungal, antioxidant and anticancer. The aim of this study was to investigate the stability and antifungal activity of liposomal dispersion with this essential oil. Liposomal dispersion stability was evaluated by testing the vesicle size, polydispersity index and zeta potential. It was also examined the in vitro release of thymol and carvacrol from liposomal dispersion.

The major components of this essential oil were carvacrol (58.4%), thymol (12.5%) and γ-terpinene (10.7%). Origanum compactum essential oil showed a strong antifungal activity, and the inhibition zones ranged from 24 to 45 mm. After 210 minutes, 80.88% thymol and 16.67% carvacrol were released. Stability assessment was performed for three months and the liposomal dispersion showed a good stability.

Pages: 192-196  |  310 Views  111 Downloads


Journal of Pharmacognosy and Phytochemistry Journal of Pharmacognosy and Phytochemistry
How to cite this article:
Merima Ibišević, Ivana Nešić, Saša Pilipović, Aida Smajlović, Nahida Srabović, Vesna Nikolić, Dragan Cvetković, Ermina Cilović Kozarević, Emir Horozić, Enida Karić and Goran Nikolić. In vitro release and stability assessment of Origanum compactum liposomal dispersion with antifungal activity. J Pharmacogn Phytochem 2022;11(2):192-196. DOI: 10.22271/phyto.2022.v11.i2c.14384

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