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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 11, Issue 3 (2022)

Formulation and evaluation of polyherbal capsules containing combination of Terminalia arjuna, Chrysanthemum indicum and Moringa oleifera

Author(s):

Shubhangi Bhide and Dr. Vikas Jain

Abstract:

Natural medicine, especially from herbs, is the source for the research of various novel medicinal compounds. Drugs from herbal origin must be ensured as safe before used as medicine.

Objective: The present work focused on the formulation, development and evaluation of polyherbal capsule containing ethanolic extracts of Bark of Terminalia arjuna, flowers of Chrysanthemum indicum, leaves of Moringa oleifera.

Methods: The ethanolic extract of all three plants were taken for the formulation and combination of all three extract was selected for the formulation of the capsule. The combination of three ethanolic extracts (CTEE) which include Bark of Terminalia arjuna, flowers of Chrysanthemum indicum and leaves of Moringa oleifera was selected as a sample material. The material was weighed, sampled, authenticated and analyzed for their compliance to quality standards. Evaluation of the capsules was done based on different parameters.

Results: Preliminary phytochemical screening of CTEE revealed the presence of major phytochemical groups such as alkaloids, carbohydrates, tannins, steroids and sterols, triterpenoids, saponins and flavonoids. As per the standards, the flow property of the blend to be filled in the capsules should be in good range and was confirmed by the above parameters. Trial batch- 3 showed excellent flow characters and that batch was taken for capsule filling. Physical parameters Moisture content-3.6%±0.22, Uniformity of weight-268 mg ± 4.5mg, Disintegration time-3.32 (min) ± 0.34, pH(1% aqueous solution)- 7.33 ± 0.21.

Conclusion: To enhance the acceptability of the herbal medicine by consumers, many of the products have been formulated into conventional dosage forms such as tablets, capsules, suspensions, and powders. CTEE were used in this study to formulate a unit solid dosage form (capsule) to increase the compliances, acceptability and adaptation of the consumers. As it is also very important to estimate the pharmaceutical quality of the Herbal products irrespective of their medicinal content and therapeutic states; so in the present study, the pre-formulation and formulation studies of the formulated capsules. Absorption of drug in the blood is controlled by the availability of drug from solid dosage into the GI fluid. Hence the rate of absorption and availability may be improved by improving the disintegration and the rate of dissolution of drug. Capsule has been successfully formulated.

Pages: 250-259  |  1518 Views  1012 Downloads


Journal of Pharmacognosy and Phytochemistry Journal of Pharmacognosy and Phytochemistry
How to cite this article:
Shubhangi Bhide and Dr. Vikas Jain. Formulation and evaluation of polyherbal capsules containing combination of Terminalia arjuna, Chrysanthemum indicum and Moringa oleifera. J Pharmacogn Phytochem 2022;11(3):250-259.

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