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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 11, Issue 4 (2022)

Screening of Psophocarpus tetragonalobus hydroalcoholic extract for antidiabetic activity on STZ induced diabetic rat model

Author(s):

Dhanya Rajan EP, Rakesh K Jatt, Sujith S Nair and Sreena K

Abstract:

Psophocarpus tetragonalobus of the Fabaceae commonly known as winged bean is a valuable crop because of its high nutritional value. The present work aims to evaluate the active potentials of different extracts of P.tetragonalobus along with its anti-diabetic activity on STZ induced diabetic rat model. Preliminary phytochemical investigation reported the presence of proteins, lipids, carbohydrates, phenolic compounds, glycosides, tannins and vitamins. Antihyperglycemic activity of the two doses (100mg/kg, 200 mg/kg) of hydroalcoholic pod extract was studied on normal, and streptozotocin-induced diabetic rat models. The effect of the extract on body weight and serum lipid levels was also examined. Out of the two doses of the plant extract 200 mg/kg showed a significant anti- diabetic activity and improved the body weight loss after repeated daily dose administration for 21 days. This study concludes that the hydro-alcoholic extract of P.tetragonalobus possesses considerable activity to reduce the blood sugar level justifying the traditional use of the plant for diabetes.

Pages: 80-88  |  446 Views  205 Downloads


Journal of Pharmacognosy and Phytochemistry Journal of Pharmacognosy and Phytochemistry
How to cite this article:
Dhanya Rajan EP, Rakesh K Jatt, Sujith S Nair and Sreena K. Screening of Psophocarpus tetragonalobus hydroalcoholic extract for antidiabetic activity on STZ induced diabetic rat model. J Pharmacogn Phytochem 2022;11(4):80-88.

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