Dr. Harshitha Venkatesh and Dr. Shivaprasad Huded

Although Ayurvedic medicines are widely used for the prevention, diagnosis, treatment, and management of disease, it has been facing constant challenges like quality control, Standardization, and pharmacokinetic profile of biomarkers in the formulation. Pharmacokinetics which deals with the absorption, distribution, metabolism and excretion of the biomarkers or the new drug entity is one of the regulatory requirements for an investigation new drug approval. Hence bioactive guided pharmacokinetic approach method is needed for Ayurvedic system of medicine to determine the pharmacokinetic of relevant markers in the formulation having number of markers. With this background, the present study has been taken with the objective to explore the importance of pharmacokinetics of the drug and evaluate the bioavailability of Guduchi Kashaya in blood plasma using LCMS MS analysis ^[1].

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