Diabaté Daouda, Zougrou N’guessan Ernest, Koné Allassane and Kouakou Koffi

Clerodendrum splendens (Lamiaceae) is a plant with therapeutic properties, traditionally used in several countries for the treatment of several diseases. The aim of this study was to evaluate the toxicity of the total aqueous extract obtained from the leaves of C. splendens in order to contribute to a better knowledge of the therapeutic effects of this plant. It consisted of a phytochemical study which was carried out according to the classical method used in natural substance chemistry for the search of secondary metabolites. It revealed the presence of polyterpenes, polyphenols, flavonoids, catechic tannins, alkaloids and saponosides. Acute toxicity, which was carried out by oral administration of ETAC to rats, showed that the LD50 was greater than 5000 mg/kg bw. For subacute toxicity, there was no significant difference in the body weights of treated rats compared to controls. Histological sections showed no structural or functional abnormalities in the thymus, spleen and kidney.

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