Soumya Kanti Biswas, Suranjana Dana, Piyali Sanyal Pathak and Mradu Gupta

This study evaluated potential antioxidant and alpha (α)-amylase and alpha (α)-glucosidase inhibition properties of Oroxylum indicum (L.) Kurz, a medicinal plant growing in North-Eastern region in India. The plant extracts was examined for its antioxidant activity by using free radical 1, 1-dipheny l-2-picryl hydrazyl (DPPH) scavenging method, ABTS radical scavenging ability, reducing power capacity, estimation of total phenolic content, flavonoid content and flavone content. The study revealed that the different concentrations of the extract possessed promising amount of total phenolics, flavonoid and flavonol and exhibit potent radical scavenging activity using DPPH and ABTS as substrate. Water extract exhibited promising α-amylase and α-glucosidase inhibitory activities with an IC₅₀ value 0.75 µg and 0.80 µg dry extract respectively and well compared with standard acarbose drug. Thus, it could be concluded that the plant extract has good potential for the management of hyperglycaemia, diabetes and the associated condition of oxidative stress due to the presence of antioxidant components. With the aid of this understanding, new effective anti-diabetic principles will be discovered from natural resources for the development of anti-diabetic medicines.

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