Amal Feki, Intissar Kammoun, Manel Naifar, Rim Kallel, Fatma Makni Ayadi, Tahia Boudawara, Moncef Nasri and Ibtissem Ben Amara

Hepatotoxicity occurs as a result of deleterious effects of some xenobiotics on the liver. Methyl thiophanate (MT), used as a fungicide, is an environmental poison established to induce organ toxicity. The current study reported the protective effect of red marine macro-alga Falkenbergia rufolanosa against MT-induced hepatotoxicity in adult Wistar rats. The animals were divided into four groups: group 1 used as a control group, group 2 received MT (300 mg/kg) by intraperitoneally injection, group 3 received MT (300 mg/kg) along with alga methanolic extract (150 mg/kg via their diet), and group 4 received only the algal extract (150 mg/kg via their diet). Up to MT treatment, results showed in increased levels of malondialdehyde, advanced oxidation protein product, and protein carbonyl groups, as well as disruption of the antioxidant defense status. In addition, significant perturbations in morphological parameters followed by a disruption in plasma biomarkers, lipid profile and histological observations in hepatic tissue were depicted, after MT injection. Nevertheless, co-treatment with algal extract appeared to be effective against MT-induced hepatotoxicity as shown by an improvement of the oxidative stress biomarkers, plasma biochemical parameters and histological injuries.

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