Abhijeet Ojha, Arun Kumar Singh, Navin Chandra Pant and Anshita Saini
Topical therapy is highly desirable in treating nail disorders due to its localized effects, which results in minimal adverse systemic events and possibly improved adherence. However, the effectiveness of topical therapies is limited by minimal drug permeability through the nail plate. Infections of foot and hand nails by fungi are a very common condition in millions of people. They account for about half of all nail disorders and are estimated to occur in over 10% of the population. Griseofulvin is an antifungal medication which acts by restraining microtubules and blocking contagious mitosis, consequently a fungistatic. Orally griseofulvin has a long elimination half-life (9-21 hrs), highly variable bioavailability (25to70%), Hepatic demethylation and glucuronidation metabolism and frequent doses(500 to 1000mg) for adult and (11mg) for children. Katha(catechu) is an imperative restorative plant utilized as a part of Ayurveda for such a variety of sicknesses and generally for mother healthcare. Solvent casting technique was used to prepare the bio-adhesive layers. Nine formulations were prepared by using griseofulvin(drug), acacia catechu as bio-penetrant, beetroot as bio-polymer and fructose as film ability. The bio-adhesive layers were physically examined for color and evaluated for thickness, weight uniformity test, folding endurance, Spectral studies, stability studies, in-vitro & ex-vivo studies.
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