Sarmin Akter Shochona and Md. Abdul Mannan

In a recent study, experimental mouse models were used to assess the central nervous system (CNS) depressive action of methanolic extract of Alpinia calcarata. The methanolic extract of Alpinia calcarata was tested for central nervous system (CNS) depressant action in adult mice using the open field, hole cross, tail suspension, forced swimming, and thiopental sodium-induced sleeping duration tests at dosages of 50, 100, and 200 mg/kg. Deionized water served as the control group, and three test groups each got a different dose of MEAC in addition to a conventional medicine called diazepam (1 mg/kg). Gavage was used to deliver all drugs orally. In both mouse models of depression, such as the open field and hole cross test, the plant extract at dosages of 50, 100, and 200 mg/kg significantly reduced locomotor activity (p<0.05). When tested in the tail suspension and forced swimming tests, the extract enhanced the immobility period at dosages of 100 and 200 mg/kg considerably (p<0.05). However, as compared to the control group, the extract also significantly (p<0.05) delayed the start of thiopental sodium-induced sleep and prolonged the amount of time spent sleeping in the test animals. In all mouse studies, MEAC demonstrated potent and dose-dependent depressing action. The current study's findings suggest that A. calcarata's methanolic extract exhibits central nervous system (CNS) depressive action. However, further investigation is underway to determine the exact phytoconstituents that are responsible for CNS depressant activity of MEAC.

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