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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 12, Issue 1 (2023)

Antioxidant activity and effect of selected herbal remedies on liver and kidney functions of wistar rats

Author(s):

JC Ngumah, JN Okereke, EU Ezeji and I Emeka-Nwabunnia

Abstract:

Using industry-standard laboratory techniques for analyzing antioxidant activity and biochemical estimates, the antioxidant and biochemical effects of a few herbal treatments offered in Owerri on Wistar rats in Imo State, Nigeria, were examined. The results showed that all samples A to D contained antioxidants and that the level of inhibition was corresponding. As the number of antioxidants in the herbal medicines (ug/ml) increased, the level of inhibition also increased. To check for toxicity, the animals' ALP, ALT, AST, total bilirubin, and direct bilirubin levels were measured. The four herbal treatments did not harm the rats' livers in any way, according to the results of AST and ALT tests. However, there was a rise in ALP and total bilirubin at doses of 12. 4 mg/kg and 16.32 mg/kg, respectively with the oversight teams. The study's large and little rises in ALP and total bilirubin levels are a clue that the four herbal treatments may have harmed the liver's ability to eliminate bilirubin. When treated with a high dose of sample D of the herbal treatment, the high value of ALP (173.98 82.00) is a clear sign of liver damage. Furthermore, the rat may be experiencing dehydration, hyperventilation, congestive heart valve, or prostatic or other types of urinary blockage due to the high levels of chloride seen in samples A (34.741.94 mEq/L), B (34.865.98 mEq/L and 35.435.17 mEq/L), and D (34.913.71 mEq/L). As a result, it is crucial to raise public knowledge about the security and impending health danger related to the use of herbal products.

Pages: 280-286  |  470 Views  166 Downloads


Journal of Pharmacognosy and Phytochemistry Journal of Pharmacognosy and Phytochemistry
How to cite this article:
JC Ngumah, JN Okereke, EU Ezeji and I Emeka-Nwabunnia. Antioxidant activity and effect of selected herbal remedies on liver and kidney functions of wistar rats. J Pharmacogn Phytochem 2023;12(1):280-286. DOI: 10.22271/phyto.2023.v12.i1d.14586

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