Sharaibi OJ, Omolokun KT, Oluwa OK, Ogbe AA and Adebayo AO

Nigeria and Africa are good repositories of great diversity of therapeutic plants which are traditionally used to treat myriads of ailments and diseases. Dysphania ambrosioides is one of the valuable medicinal plants in African folk medicine known for its anti-inflammatory, antifungal, anti-diarrhoea, anti-diabetic, and purgative properties. Hybanthus enneaspermus is an annual herb or shrub plant that contains a variety of phytoconstituents for the treatment of various acute or chronic disorders. Recent research has revealed that these plants are extensively used for therapeutic purposes in the Badagry community of Lagos State, and more research on their phytochemistry and antioxidant potentials is generally required. Thus, this present study aimed at comparing the quantities of phytochemicals and antioxidant activities of Dysphania ambrosioides L and Hybanthus enneaspermus (L) F. Muell. Different fractions of H. enneaspermus and D. ambrosioides were screened for their phytochemicals including total phenolic content, tannins content, total flavonoid content, alkaloids content and total saponins content. Also, in vitro antioxidant activity was assessed using DPPH radical scavenging, reducing power and nitric oxide assays. Other phytoconstituents were evaluated through GC-MS determination. Results showed that the ethanol fraction was found to have high levels of alkaloids (189.43 mg/g) and flavonoids (135.07 mg/g) content in both D. Ambrosioides and H. Enneaspermus respectively. At 25μg/mL and 50μg/mL, the extracts of H. Enneaspermus exhibited higher antioxidant activities than D. Ambrosioides while at 75 μg/mL and 100 μg/mL, D. Ambrosioides exhibited higher antioxidant than H. Enneaspermus. Significant phytoconstituents were discovered in both plants through GCMS determination.

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